Publications of the first year (Nov 2005-Oct 2006)

1. Abu El-Asrar,A.M., S.Struyf, D.Kangave, K.Geboes, and J.Van Damme. 2006. Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Eur. Cytokine Netw. 17:155-165.

2. Bizzarri,C., A.R.Beccari, R.Bertini, M.R.Cavicchia, S.Giorgini, and M.Allegretti. 2006. ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets. Pharmacol. Ther. 112:139-149.

3. Bottazzi,B., C.Garlanda, G.Salvatori, P.Jeannin, A.Manfredi, and A.Mantovani. 2006. Pentraxins as a key component of innate immunity. Curr. Opin. Immunol. 18:10-15.

4. Bottazzi,B., A.Bastone, A.Doni, C.Garlanda, S.Valentino, L.Deban, V.Maina, A.Cotena, F.Moalli, L.Vago, A.Salustri, L.Romani, and A.Mantovani. 2006. The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. J. Leukoc. Biol. 79:909-912.

5. Doni,A., M.Michela, B.Bottazzi, G.Peri, S.Valentino, N.Polentarutti, C.Garlanda, and A.Mantovani. 2006. Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma. J. Leukoc. Biol. 79:797-802.

6. Loos,T., L.Dekeyzer, S.Struyf, E.Schutyser, K.Gijsbers, M.Gouwy, A.Fraeyman, W.Put, I.Ronsse, B.Grillet, G.Opdenakker, J.V.Damme, and P.Proost. 2006. TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis. Lab Invest 86:902-916.

7. Mantovani,A. and F.Balkwill. 2006. RalB signaling: a bridge between inflammation and cancer. Cell 127:42-44.

8. Mantovani,A., T.Schioppa, C.Porta, P.Allavena, and A.Sica. 2006. Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 25:315-322.

9. Pawar,R.D., P.S.Patole, D.Zecher, S.Segerer, M.Kretzler, D.Schlondorff, and H.J.Anders. 2006. Toll-like receptor-7 modulates immune complex glomerulonephritis. J. Am. Soc. Nephrol. 17:141-149.

10. Pello,O.M., B.Duthey, D.Garcia-Bernal, J.M.Rodriguez-Frade, J.V.Stein, J.Teixido, C.Martinez, and M.Mellado. 2006. Opioids trigger alpha 5 beta 1 integrin-mediated monocyte adhesion. J. Immunol. 176:1675-1685.

11. Proost,P., S.Struyf, T.Loos, M.Gouwy, E.Schutyser, R.Conings, I.Ronsse, M.Parmentier, B.Grillet, G.Opdenakker, J.Balzarini, and J.Van Damme. 2006. Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies. Arthritis Res. Ther. 8:R107.

12. Rosenkilde,M.M., R.David, I.Oerlecke, T.ned-Jensen, U.Geumann, A.G.Beck-Sickinger, and T.W.Schwartz. 2006. Conformational constraining of inactive and active states of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V. Mol. Pharmacol. 70:1892-1901.

13. Sironi,M., F.O.Martinez, D.D'Ambrosio, M.Gattorno, N.Polentarutti, M.Locati, A.Gregorio, A.Iellem, M.A.Cassatella, J.Van Damme, S.Sozzani, A.Martini, F.Sinigaglia, A.Vecchi, and A.Mantovani. 2006. Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2). J. Leukoc. Biol. 80:342-349.

14. Springael,J.Y., P.N.Le Minh, E.Urizar, S.Costagliola, G.Vassart, and M.Parmentier. 2006. Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers. Mol. Pharmacol. 69:1652-1661.

Publications of the second year (Nov 2006-Oct 2007)

15. Arenzana-Seisdedos,F. and M.Parmentier. 2006. Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands. Semin. Immunol. 18:387-403.

16. Migeotte,I., D.Communi, and M.Parmentier. 2006. Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 17:501-519.

17. Patole,P.S., R.D.Pawar, M.Lech, D.Zecher, H.Schmidt, S.Segerer, A.Ellwart, A.Henger, M.Kretzler, and H.J.Anders. 2006. Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. Nephrol. Dial. Transplant. 21:3062-3073.

18. Pawar,R.D., P.S.Patole, A.Ellwart, M.Lech, S.Segerer, D.Schlondorff, and H.J.Anders. 2006. Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis. J. Am. Soc. Nephrol. 17:3365-3373.

19. Pello,O.M., M.C.Moreno-Ortiz, J.M.Rodriguez-Frade, L.Martinez-Munoz, D.Lucas, L.Gomez, P.Lucas, E.Samper, M.Aracil, C.Martinez, A.Bernad, and M.Mellado. 2006. SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade. Blood 108:3928-3937.

20. Penna,G., S.Amuchastegui, C.Cossetti, F.Aquilano, R.Mariani, F.Sanvito, C.Doglioni, and L.Adorini. 2006. Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J. Immunol. 177:8504-8511.

21. Pruenster,M. and A.Rot. 2006. Throwing light on DARC. Biochem. Soc. Trans. 34:1005-1008.

22. Schmid,H., A.Boucherot, Y.Yasuda, A.Henger, B.Brunner, F.Eichinger, A.Nitsche, E.Kiss, M.Bleich, H.J.Grone, P.J.Nelson, D.Schlondorff, C.D.Cohen, and M.Kretzler. 2006. Modular Activation of Nuclear Factor-{kappa}B Transcriptional Programs in Human Diabetic Nephropathy. Diabetes 55:2993-3003.

23. Acosta-Rodriguez,E.V., L.Rivino, J.Geginat, D.Jarrossay, M.Gattorno, A.Lanzavecchia, F.Sallusto, and G.Napolitani. 2007. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8:639-646.

24. Adorini,L., G.Penna, S.Amuchastegui, C.Cossetti, F.Aquilano, R.Mariani, B.Fibbi, A.Morelli, M.Uskokovic, E.Colli, and M.Maggi. 2007. Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol). J. Steroid Biochem. Mol. Biol. 103:689-693.

25. Adorini,L., S.Amuchastegui, E.Corsiero, G.Laverni, T.Lemeur, and G.Penna. 2007. Vitamin D receptor agonists as anti-inflammatory agents. Future Drugs - Expert Review in Clinical Immunology 3:477-489.

26. Annunziato,F., L.Cosmi, V.Santarlasci, L.Maggi, F.Liotta, B.Mazzinghi, E.Parente, L.Fili, S.Ferri, F.Frosali, F.Giudici, P.Romagnani, P.Parronchi, F.Tonelli, E.Maggi, and S.Romagnani. 2007. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204:1849-1861.

27. Bedke,J., E.Kiss, L.Schaefer, C.L.Behnes, M.Bonrouhi, N.Gretz, R.Horuk, M.edrichs-Moehring, G.Wildner, P.J.Nelson, and H.J.Grone. 2007. Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage. Am. J. Transplant. 7:527-537.

28. Bielecki,B., A.Mazurek, P.Wolinski, and A.Glabinski. 2007. Expression of chemokine receptors CCR7 and CCR8 in the CNS during ChREAE. Scand. J. Immunol. 66:383-392.

29. Braunersreuther,V., A.Zernecke, C.Arnaud, E.A.Liehn, S.Steffens, E.Shagdarsuren, K.Bidzhekov, F.Burger, G.Pelli, B.Luckow, F.Mach, and C.Weber. 2007. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 27:373-379.

30. Bruhl,H., J.Cihak, J.Plachy, L.Kunz-Schughart, M.Niedermeier, A.Denzel, G.M.Rodriguez, Y.Talke, B.Luckow, M.Stangassinger, and M.Mack. 2007. Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis. Arthritis Rheum. 56:2975-2985.

31. Colditz,I.G., M.A.Schneider, M.Pruenster, and A.Rot. 2007. Chemokines at large: in-vivo mechanisms of their transport, presentation and clearance. Thromb. Haemost. 97:688-693.

32. Combadiere,C., C.Feumi, W.Raoul, N.Keller, M.Rodero, A.Pezard, S.Lavalette, M.Houssier, L.Jonet, E.Picard, P.Debre, M.Sirinyan, P.Deterre, T.Ferroukhi, S.Y.Cohen, D.Chauvaud, J.C.Jeanny, S.Chemtob, F.Behar-Cohen, and F.Sennlaub. 2007. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J. Clin. Invest 117:2920-2928.

33. Frauenschuh,A., C.A.Power, M.Deruaz, B.R.Ferreira, J.S.Silva, M.M.Teixeira, J.M.Dias, T.Martin, T.N.Wells, and A.E.Proudfoot. 2007. Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus. J. Biol. Chem. 282:27250-27258.

34. Gao,J.L., A.Guillabert, J.Hu, Y.Le, E.Urizar, E.Seligman, K.J.Fang, X.Yuan, V.Imbault, D.Communi, J.M.Wang, M.Parmentier, P.M.Murphy, and I.Migeotte. 2007. F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor. J. Immunol. 178:1450-1456.

35. Garcia,G., M.Humbert, F.Capel, A.C.Rimaniol, P.Escourrou, D.Emilie, and V.Godot. 2007. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. Allergy 62:170-177.

36. Garlanda,C., F.Riva, T.Veliz, N.Polentarutti, F.Pasqualini, E.Radaelli, M.Sironi, M.Nebuloni, E.O.Zorini, E.Scanziani, and A.Mantovani. 2007. Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res. 67:6017-6021.

37. Giarratana,N., G.Penna, and L.Adorini. 2007. Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse. Methods Mol. Biol. 380:285-312.

38. Godot,V., M.Arock, G.Garcia, F.Capel, C.Flys, M.Dy, D.Emilie, and M.Humbert. 2007. H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12. J. Allergy Clin. Immunol. 120:827-834.

39. Gómez-Moutón,C. and S.Manes. 2007. Establishment and maintenance of cell polarity during leukocyte chemotaxis. Cell Adhesion & Migration 1:2:e1-e8.

40. Hamdi,H., V.Godot, M.C.Maillot, M.V.Prejean, N.Cohen, R.Krzysiek, F.M.Lemoine, W.Zou, and D.Emilie. 2007. Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper. Blood 110:211-219.

41. Jensen,P.C., R.Nygaard, S.Thiele, A.Elder, G.Zhu, R.Kolbeck, S.Ghosh, T.W.Schwartz, and M.M.Rosenkilde. 2007. Molecular interaction of a potent non-peptide agonist with the chemokine receptor CCR8. Mol. Pharmacol. 72:327-340.

42. Jimenez-Baranda,S., C.Gomez-Mouton, A.Rojas, L.Martinez-Prats, E.Mira, L.R.Ana, A.Valencia, D.S.Dimitrov, A.Viola, R.Delgado, A.Martinez, and S.Manes. 2007. Filamin-A regulates actin-dependent clustering of HIV receptors. Nat. Cell Biol. 9:838-846.

43. Kellenberger,E., J.Y.Springael, M.Parmentier, M.Hachet-Haas, J.L.Galzi, and D.Rognan. 2007. Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening. J. Med. Chem. 50:1294-1303.

44. Lasagni,L., R.Grepin, B.Mazzinghi, E.Lazzeri, C.Meini, C.Sagrinati, F.Liotta, F.Frosali, E.Ronconi, Alain-Court, L.Ballerini, G.S.Netti, E.Maggi, F.Annunziato, M.Serio, S.Romagnani, A.Bikfalvi, and P.Romagnani. 2007. PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood 109:4127-4134.

45. Lech,M., C.Garlanda, A.Mantovani, C.J.Kirschning, D.Schlondorff, and H.J.Anders. 2007. Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells. Kidney Int. 72:182-192.

46. Mantovani,A., A.Sica, and M.Locati. 2007. New vistas on macrophage differentiation and activation. Eur. J. Immunol. 37:14-16.

47. Martinez de laTorre,Y., C.Buracchi, E.M.Borroni, J.Dupor, R.Bonecchi, M.Nebuloni, F.Pasqualini, A.Doni, E.Lauri, C.Agostinis, R.Bulla, D.N.Cook, B.Haribabu, P.Meroni, D.Rukavina, L.Vago, F.Tedesco, A.Vecchi, S.A.Lira, M.Locati, and A.Mantovani. 2007. Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc. Natl. Acad. Sci. U. S. A 104:2319-2324.

48. Mayer,V., K.L.Hudkins, F.Heller, H.Schmid, M.Kretzler, U.Brandt, H.J.Anders, H.Regele, P.J.Nelson, C.E.Alpers, D.Schlondorff, and S.Segerer. 2007. Expression of the chemokine receptor CCR1 in human renal allografts. Nephrol. Dial. Transplant. 22:1720-1729.

49. Meuter,S., P.Schaerli, R.S.Roos, O.Brandau, M.R.Bosl, U.H.von Andrian, and B.Moser. 2007. Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Mol. Cell Biol. 27:983-992.

50. Morelli,A., L.Vignozzi, S.Filippi, G.B.Vannelli, S.Ambrosini, R.Mancina, C.Crescioli, S.Donati, B.Fibbi, E.Colli, L.Adorini, and M.Maggi. 2007. BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder. Prostate 67:234-247.

51. Moriconi,A., M.C.Cesta, M.N.Cervellera, A.Aramini, S.Coniglio, S.Colagioia, A.R.Beccari, C.Bizzarri, M.R.Cavicchia, M.Locati, E.Galliera, B.P.Di, P.Vigilante, R.Bertini, and M.Allegretti. 2007. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J. Med. Chem. 50:3984-4002.

52. Ninichuk,V., A.G.Khandoga, S.Segerer, P.Loetscher, A.Schlapbach, L.Revesz, R.Feifel, A.Khandoga, F.Krombach, P.J.Nelson, D.Schlondorff, and H.J.Anders. 2007. The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. Am. J. Pathol. 170:1267-1276.

53. Parolini,S., A.Santoro, E.Marcenaro, W.Luini, L.Massardi, F.Facchetti, D.Communi, M.Parmentier, A.Majorana, M.Sironi, G.Tabellini, A.Moretta, and S.Sozzani. 2007. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood 109:3625-3632.

54. Patole,P.S., R.D.Pawar, J.Lichtnekert, M.Lech, O.P.Kulkarni, A.Ramanjaneyulu, S.Segerer, and H.J.Anders. 2007. Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis. J. Autoimmun. 29:52-59.

55. Pawar,R.D., A.Ramanjaneyulu, O.P.Kulkarni, M.Lech, S.Segerer, and H.J.Anders. 2007. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J. Am. Soc. Nephrol. 18:1721-1731.

56. Penna,G., N.Mondaini, S.Amuchastegui, I.S.Degli, M.Carini, G.Giubilei, B.Fibbi, E.Colli, M.Maggi, and L.Adorini. 2007. Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Eur. Urol. 51:524-533.

57. Penna,G., S.Amuchastegui, N.Giarratana, K.C.Daniel, M.Vulcano, S.Sozzani, and L.Adorini. 2007. 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J. Immunol. 178:145-153.

58. Penna,G., S.Amuchastegui, C.Cossetti, F.Aquilano, R.Mariani, N.Giarratana, C.E.De, B.Fibbi, and L.Adorini. 2007. Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse. J. Immunol. 179:1559-1567.

59. Proost,P., A.Mortier, T.Loos, J.Vandercappellen, M.Gouwy, I.Ronsse, E.Schutyser, W.Put, M.Parmentier, S.Struyf, and J.Van Damme. 2007. Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. Blood 110:37-44.

60. Rosenkilde,M.M., M.B.Andersen, R.Nygaard, T.M.Frimurer, and T.W.Schwartz. 2007. Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI. Mol. Pharmacol. 71:930-941.

61. Rosenkilde,M.M., L.O.Gerlach, S.Hatse, R.T.Skerlj, D.Schols, G.J.Bridger, and T.W.Schwartz. 2007. Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J. Biol. Chem. 282:27354-27365.

62. Schneider,M.A., J.G.Meingassner, M.Lipp, H.D.Moore, and A.Rot. 2007. CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J. Exp. Med. 204:735-745.

63. Schutyser,E., Y.Su, Y.Yu, M.Gouwy, S.Zaja-Milatovic, J.Van Damme, and A.Richmond. 2007. Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells. Eur. Cytokine Netw. 18:59-70.

64. Segerer,S., R.Djafarzadeh, H.J.Grone, C.Weingart, D.Kerjaschki, C.Weber, A.J.Kungl, H.Regele, A.E.Proudfoot, and P.J.Nelson. 2007. Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation. J. Am. Soc. Nephrol. 18:1835-1844.

65. Sohy,D., M.Parmentier, and J.Y.Springael. 2007. Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J. Biol. Chem. 282:30062-30069.

66. Springael,J.Y., E.Urizar, S.Costagliola, G.Vassart, and M.Parmentier. 2007. Allosteric properties of G protein-coupled receptor oligomers. Pharmacol. Ther. 115:410-418.

67. Springael,J.Y.,, X.Deupi, J.Van Damme, L.Pardo, and M.Parmentier. 2007. The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin. Cell Signal. 19:1446-1456.

68. Vielhauer,V., H.J.Anders, and D.Schlondorff. 2007. Chemokines and chemokine receptors as therapeutic targets in lupus nephritis. Semin. Nephrol. 27:81-97.

Publications of the third year (Nov 2007-Oct 2008)

69. Mantovani,A., C.Garlanda, M.Locati, T.V.Rodriguez, S.G.Feo, B.Savino, and A.Vecchi. 2007. Regulatory pathways in inflammation. Autoimmun. Rev. 7:8-11.

70. Hamdi,H., A.Bigorgne, S.Naveau, A.Balian, L.Bouchet-Delbos, A.M.Cassard-Doulcier, M.C.Maillot, I.Durand-Gasselin, S.Prevot, J.Delaveaucoupet, D.Emilie, and G.Perlemuter. 2007. Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis. Hepatology 46:1986-1992.

71. Manzo,A., S.Bugatti, R.Caporali, R.Prevo, D.G.Jackson, M.Uguccioni, C.D.Buckley, C.Montecucco, and C.Pitzalis. 2007. CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. Am. J. Pathol. 171:1549-1562.

72. Lacalle,R.A., R.M.Peregil, J.P.Albar, E.Merino, A.Martinez, I.Merida, and S.Manes. 2007. Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement. J. Cell Biol. 179:1539-1553.

73. Thelen,M. and J.V.Stein. 2008. How chemokines invite leukocytes to dance. Nat. Immunol. 9:953-959.

74. Gregoire,C., C.Cognet, L.Chasson, C.A.Coupet, M.Dalod, A.Reboldi, J.Marvel, F.Sallusto, E.Vivier, and T.Walzer. 2008. Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation. Eur. J. Immunol. 38:2076-2084.

75. Liotta,F., F.Frosali, V.Querci, A.Mantei, L.Fili, L.Maggi, B.Mazzinghi, R.Angeli, E.Ronconi, V.Santarlasci, T.Biagioli, L.Lasagni, C.Ballerini, P.Parronchi, A.Scheffold, L.Cosmi, E.Maggi, S.Romagnani, and F.Annunziato. 2008. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J. Allergy Clin. Immunol. 121:1000-1005.

76. Cosmi,L., P.R.De, V.Santarlasci, L.Maggi, M.Capone, F.Frosali, G.Rodolico, V.Querci, G.Abbate, R.Angeli, L.Berrino, M.Fambrini, M.Caproni, F.Tonelli, E.Lazzeri, P.Parronchi, F.Liotta, E.Maggi, S.Romagnani, and F.Annunziato. 2008. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J. Exp. Med. 205:1903-1916.

77. Vandercappellen,J., J.Van Damme, and S.Struyf. 2008. The role of CXC chemokines and their receptors in cancer. Cancer Lett. 267:226-244.

78. Gouwy,M., S.Struyf, S.Noppen, E.Schutyser, J.Y.Springael, M.Parmentier, P.Proost, and J.Van Damme. 2008. Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol. Pharmacol. 74:485-495.

79. Ninichuk,V., S.Clauss, O.Kulkarni, H.Schmid, S.Segerer, E.Radomska, D.Eulberg, K.Buchner, N.Selve, S.Klussmann, and H.J.Anders. 2008. Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. Am. J. Pathol. 172:628-637.

80. von Luettichau,I., S.Segerer, A.Wechselberger, M.Notohamiprodjo, M.Nathrath, M.Kremer, A.Henger, R.Djafarzadeh, S.Burdach, R.Huss, and P.J.Nelson. 2008. A complex pattern of chemokine receptor expression is seen in osteosarcoma. BMC. Cancer 8:23.

81. Lech,M., O.P.Kulkarni, S.Pfeiffer, E.Savarese, A.Krug, C.Garlanda, A.Mantovani, and H.J.Anders. 2008. Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J. Exp. Med. 205:1879-1888.

82. Zerwes,H.G., J.Li, J.Kovarik, M.Streiff, M.Hofmann, L.Roth, M.Luyten, C.Pally, R.P.Loewe, G.Wieczorek, R.Banteli, G.Thoma, and B.Luckow. 2008. The chemokine receptor Cxcr3 is not essential for acute cardiac allograft rejection in mice and rats. Am. J. Transplant. 8:1604-1613.

83. Raoul,W., N.Keller, M.Rodero, F.Behar-Cohen, F.Sennlaub, and C.Combadiere. 2008. Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells. J. Neuroimmunol. 198:56-61.

84. Bigorgne,A.E., L.Bouchet-Delbos, S.Naveau, I.Dagher, S.Prevot, I.Durand-Gasselin, J.Couderc, P.Valet, D.Emilie, and G.Perlemuter. 2008. Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of Fatty liver inflammation in obese mice. Gastroenterology 134:1459-1469.

85. Adalid-Peralta,L., A.Mathian, T.Tran, L.Delbos, I.Durand-Gasselin, D.Berrebi, M.Peuchmaur, J.Couderc, D.Emilie, and S.Koutouzov. 2008. Leukocytes and the kidney contribute to interstitial inflammation in lupus nephritis. Kidney Int. 73:172-180.

86. Wengner,A.M., S.C.Pitchford, R.C.Furze, and S.M.Rankin. 2008. The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood 111:42-49.

87. Barsante,M.M., T.M.Cunha, M.Allegretti, F.Cattani, F.Policani, C.Bizzarri, W.L.Tafuri, S.Poole, F.Q.Cunha, R.Bertini, and M.M.Teixeira. 2008. Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats. Br. J. Pharmacol. 153:992-1002.

88. Coelho,F.M., V.Pinho, F.A.Amaral, D.Sachs, V.V.Costa, D.H.Rodrigues, A.T.Vieira, T.A.Silva, D.G.Souza, R.Bertini, A.L.Teixeira, and M.M.Teixeira. 2008. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum. 58:2329-2337.

89. Cunha,T.M., M.M.Barsante, A.T.Guerrero, W.A.Verri, Jr., S.H.Ferreira, F.M.Coelho, R.Bertini, G.C.Di, M.Allegretti, F.Q.Cunha, and M.M.Teixeira. 2008. Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice. Br. J. Pharmacol. 154:460-470.

90. Jensen,P.C., S.Thiele, T.Ulven, T.W.Schwartz, and M.M.Rosenkilde. 2008. Positive Versus Negative Modulation of Different Endogenous Chemokines for CC-chemokine Receptor 1 by Small Molecule Agonists through Allosteric Versus Orthosteric Binding. J. Biol. Chem. 283:23121-23128.

91. Mellado,M. and Y.R.Carrasco. 2008. Imaging techniques: New insights into chemokine/chemokine receptor biology at the immune system. Pharmacol. Ther. 119:24-32.

92. Mazzinghi,B., E.Ronconi, E.Lazzeri, C.Sagrinati, L.Ballerini, M.L.Angelotti, E.Parente, R.Mancina, G.S.Netti, F.Becherucci, M.Gacci, M.Carini, L.Gesualdo, M.Rotondi, E.Maggi, L.Lasagni, M.Serio, S.Romagnani, and P.Romagnani. 2008. Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J. Exp. Med. 205:479-490.

93. Petrai,I., K.Rombouts, L.Lasagni, F.Annunziato, L.Cosmi, R.G.Romanelli, C.Sagrinati, B.Mazzinghi, M.Pinzani, S.Romagnani, P.Romagnani, and F.Marra. 2008. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. Int. J. Biochem. Cell Biol. 40:1764-1774.

94. Contento,R.L., B.Molon, C.Boularan, T.Pozzan, S.Manes, S.Marullo, and A.Viola. 2008. CXCR4-CCR5: a couple modulating T cell functions. Proc. Natl. Acad. Sci. U. S. A 105:10101-10106.

95. Mira,E., B.Leon, D.F.Barber, S.Jimenez-Baranda, I.Goya, L.Almonacid, G.Marquez, A.Zaballos, A.Martinez, J.V.Stein, C.Ardavin, and S.Manes. 2008. Statins induce regulatory T cell recruitment via a CCL1 dependent pathway. J. Immunol. 181:3524-3534.

96. Raoul,W., N.Keller, M.Rodero, F.Behar-Cohen, F.Sennlaub, and C.Combadiere. 2008. Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells. J. Neuroimmunol. 198:56-61.

97. Raoul,W., C.Feumi, N.Keller, S.Lavalette, M.Houssier, F.Behar-Cohen, C.Combadiere, and F.Sennlaub. 2008. Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. Ophthalmic Res. 40:115-119.

98. Chelbi,H., A.Ghadiri, J.Lacheb, P.Ghandil, K.Hamzaoui, A.Hamzaoui, and C.Combadiere. 2008. A polymorphism in the CCL2 chemokine gene is associated with asthma risk: a case-control and a family study in Tunisia. Genes Immun. [Epub ahead of print].

99. Combadiere,C., S.Potteaux, M.Rodero, T.Simon, A.Pezard, B.Esposito, R.Merval, A.Proudfoot, A.Tedgui, and Z.Mallat. 2008. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice. Circulation 117:1649-1657.

100. Combadiere,C., O.Godin, C.Vidal, A.Cangialosi, C.Proust, and C.Tzourio. 2008. Common CX3CR1 alleles are associated with a reduced risk of headaches. Headache 48:1061-1066.

101. Dorgham,K., V.Abadie, M.Iga, O.Hartley, G.Gorochov, and B.Combadiere. 2008. Engineered CCR5 superagonist chemokine as adjuvant in anti-tumor DNA vaccination. Vaccine 26:3252-3260.

102. Borroni,E.M., R.Bonecchi, C.Buracchi, B.Savino, A.Mantovani, and M.Locati. 2008. Chemokine decoy receptors: new players in reproductive immunology. Immunol. Invest 37:483-497.

103. Bonecchi,R., E.M.Borroni, B.Savino, C.Buracchi, A.Mantovani, and M.Locati. 2008. Non-signaling chemokine receptors: Mechanism of action and role in vivo. J. Neuroimmunol. 198:14-19.

104. Bonecchi,R., E.M.Borroni, A.Anselmo, A.Doni, B.Savino, M.Mirolo, M.Fabbri, V.R.Jala, B.Haribabu, A.Mantovani, and M.Locati. 2008. Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood 112:493-503.

105. Allegretti,M., R.Bertini, C.Bizzarri, A.Beccari, A.Mantovani, and M.Locati. 2008. Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls. Trends Pharmacol. Sci. 29:280-286.

106. Martinez,F.O., A.Sica, A.Mantovani, and M.Locati. 2008. Macrophage activation and polarization. Front Biosci. 13:453-461.

107. Garlanda,C., V.Maina, T.Y.Martinez de la, M.Nebuloni, and M.Locati. 2008. Inflammatory Reaction and Implantation: the New Entries PTX3 and D6. Placenta. [Epub ahead of print].

108. Allavena,P., A.Sica, C.Garlanda, and A.Mantovani. 2008. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol. Rev. 222:155-161.

109. Allavena,P., C.Garlanda, M.G.Borrello, A.Sica, and A.Mantovani. 2008. Pathways connecting inflammation and cancer. Curr. Opin. Genet. Dev. 18:3-10.

110. McKimmie,C.S., A.R.Fraser, C.Hansell, L.Gutierrez, S.Philipsen, L.Connell, A.Rot, M.Kurowska-Stolarska, P.Carreno, M.Pruenster, C.C.Chu, G.Lombardi, C.Halsey, I.B.McInnes, F.Y.Liew, R.J.Nibbs, and G.J.Graham. 2008. Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. J. Immunol. 181:3353-3363.

111. Barone,F., M.Bombardieri, M.M.Rosado, P.R.Morgan, S.J.Challacombe, V.S.De, R.Carsetti, J.Spencer, G.Valesini, and C.Pitzalis. 2008. CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J. Immunol. 180:5130-5140.

112. Pello,O.M., L.Martinez-Munoz, V.Parrillas, A.Serrano, J.M.Rodriguez-Frade, M.J.Toro, P.Lucas, M.Monterrubio, A.Martinez, and M.Mellado. 2008. Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur. J. Immunol. 38:537-549.

113. Mellado,M., A.A.Martin de, L.Gomez, C.Martinez, and J.M.Rodriguez-Frade. 2008. Chemokine receptor 2 blockade prevents asthma in a cynomolgus monkey model. J. Pharmacol. Exp. Ther. 324:769-775.

114. Mirolo,M., M.Fabbri, M.Sironi, A.Vecchi, A.Guglielmotti, G.Mangano, G.Biondi, M.Locati, and A.Mantovani. 2008. Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins. Eur. Cytokine Netw. 19:119-122.

115. Hermand,P., F.Pincet, S.Carvalho, H.Ansanay, E.Trinquet, M.Daoudi, C.Combadiere, and P.Deterre. 2008. Functional adhesiveness of the CX3CLl1 chemokine requires its aggregation: Role of the transmembrane domain. J. Biol. Chem. 28:30225-34.

116. Mortier,A., J.Van Damme, and P.Proost. 2008. Regulation of chemokine activity by posttranslational modification. Pharmacol. Ther. [Epub ahead of print].

117. Deruaz,M., A.Frauenschuh, A.L.Alessandri, J.M.Dias, F.M.Coelho, R.C.Russo, B.R.Ferreira, G.J.Graham, J.P.Shaw, T.N.Wells, M.M.Teixeira, C.A.Power, and A.E.Proudfoot. 2008. Ticks produce highly selective chemokine binding proteins with antiinflammatory activity. J. Exp. Med. 205:2019-2031.

118. Di Liberto,D., M.Locati, N.Caccamo, A.Vecchi, S.Meraviglia, A.Salerno, G.Sireci, M.Nebuloni, N.Caceres, P.J.Cardona, F.Dieli, and A.Mantovani. 2008. Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. J. Exp. Med. 205:2075-2084.

119. Proost,P., T.Loos, A.Mortier, E.Schutyser, M.Gouwy, S.Noppen, C.Dillen, I.Ronsse, R.Conings, S.Struyf, G.Opdenakker, P.C.Maudgal, and J.Van Damme. 2008. Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. J. Exp. Med. 205:2085-2097.

120. Loos,T., A.Mortier, M.Gouwy, I.Ronsse, W.Put, J.P.Lenaerts, J.Van Damme, and P.Proost. 2008. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood 112:2648-2656.

121. Handel,T.M., Z.Johnson, D.H.Rodrigues, A.C.Dos Santos, R.Cirillo, V.Muzio, S.Riva, M.Mack, M.Deruaz, F.Borlat, P.A.Vitte, T.N.Wells, M.M.Teixeira, and A.E.Proudfoot. 2008. An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J. Leukoc. Biol. 84:1101-1108.

122. Bendz,H., B.C.Marincek, F.Momburg, J.W.Ellwart, R.D.Issels, P.J.Nelson, and E.Noessner. 2008. Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation. J. Biol. Chem. 283:26477-26483.

123. Benned-Jensen,T. and M.M.Rosenkilde. 2008. Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist. Mol. Pharmacol. 74:1008-1021.

124. Russo,R.C.; Guabiraba,R.; Garcia,C.C.; Barcelos,L.S.; Roffe,E.; Souza,A.L.; Amaral,F.A.; Cisalpino,D.; Cassali,G.D.; Doni,A.; Bertini,R.; Teixeira,M.M. 2008. Role of the Chemokine Receptor CXCR2 in Bleomycin-induced Pulmonary Inflammation and Fibrosis. Am.J.Respir.Cell Mol.Biol. [Epub ahead of print].

Publications of the fourth year (Nov 2008-Oct 2009)

125. Annunziato,F., L.Cosmi, F.Liotta, E.Maggi, and S.Romagnani. 2008. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Immunol 20:1361-1368.

126. Guillabert,A., V.Wittamer, B.Bondue, V.Godot, V.Imbault, M.Parmentier, and D.Communi. 2008. Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation. J Leukoc Biol 84:1530-1538.

127. Kulkarni,O. and H.J.Anders. 2008. Chemokines in lupus nephritis. Front Biosci 13:3312-3320.

128. Loos,T., A.Mortier, M.Gouwy, I.Ronsse, W.Put, J.P.Lenaerts, J.Van Damme, and P.Proost. 2008. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood 112:2648-2656.

129. Vermi,W., S.Lonardi, D.Bosisio, M.Uguccioni, G.Danelon, S.Pileri, C.Fletcher, S.Sozzani, F.Zorzi, G.Arrigoni, C.Doglioni, M.Ponzoni, and F.Facchetti. 2008. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. J Pathol 216:356-364.

130. Manzo,A., B.Vitolo, F.Humby, R.Caporali, D.Jarrossay, F.Dell'accio, L.Ciardelli, M.Uguccioni, C.Montecucco, and C.Pitzalis. 2008. Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint. Arthritis Rheum. 58:3377-3387.

131. Albanesi,C., C.Scarponi, S.Pallotta, R.Daniele, D.Bosisio, S.Madonna, P.Fortugno, S.Gonzalvo-Feo, J.D.Franssen, M.Parmentier, O.De Pita, G.Girolomoni, and S.Sozzani. 2009. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med 206:249-258.

132. Annunziato,F. and S.Romagnani. 2009. Do studies in humans better depict Th17 cells? Blood 114:2213-2219.

133. Barcelos,L.S., A.M.Coelho, R.C.Russo, R.Guabiraba, A.L.Souza, G.Bruno-Lima, Jr., A.E.Proudfoot, S.P.Andrade, and M.M.Teixeira. 2009. Role of the chemokines CCL3/MIP-1 alpha and CCL5/RANTES in sponge-induced inflammatory angiogenesis in mice. Microvasc Res 78:148-154.

134. Clauss,S., O.Gross, O.Kulkarni, A.Avila-Ferrufino, E.Radomska, S.Segerer, D.Eulberg, S.Klussmann, and H.J.Anders. 2009. Ccl2/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy. J Pathol 218:40-47.

135. Conrad,C., H.Niess, R.Huss, S.Huber, I.von Luettichau, P.J.Nelson, H.C.Ott, K.W.Jauch, and C.J.Bruns. 2009. Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. Circulation 119:281-289.

136. Devosse,T., A.Guillabert, N.D'Haene, A.Berton, P.De Nadai, S.Noel, M.Brait, J.D.Franssen, S.Sozzani, I.Salmon, and M.Parmentier. 2009. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. J Immunol 182:4974-4984.

137. Dorgham,K., A.Ghadiri, P.Hermand, M.Rodero, L.Poupel, M.Iga, O.Hartley, G.Gorochov, C.Combadiere, and P.Deterre. 2009. An engineered CX3CR1 antagonist endowed with anti-inflammatory activity. J Leukoc Biol.

138. Kumar,D., J.Hosse, C.von Toerne, E.Noessner, and P.J.Nelson. 2009. JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1. J Immunol 182:1011-1020.

139. Loos,T., G.Opdenakker, J.Van Damme, and P.Proost. 2009. Citrullination of CXCL8 increases its potency to mobilize neutrophils in the blood circulation. Haematologica.

140. Luckow,B., A.Hanggli, H.Maier, S.Chilla, R.P.Loewe, S.Dehmel, D.Schlondorff, P.Loetscher, H.G.Zerwes, and M.Muller. 2009. Microinjection of Cre recombinase protein into zygotes enables specific deletion of two eukaryotic selection cassettes and enhances the expression of a DsRed2 reporter gene in Ccr2/Ccr5 double-deficient mice. Genesis 47:545-558.

141. Michiels,K., E.Schutyser, R.Conings, J.P.Lenaerts, W.Put, S.Nuyts, P.Delaere, R.Jacobs, S.Struyf, P.Proost, and J.Van Damme. 2009. Carcinoma cell-derived chemokines and their presence in oral fluid. Eur J Oral Sci 117:362-368.

142. Pitchford,S.C., R.C.Furze, C.P.Jones, A.M.Wengner, and S.M.Rankin. 2009. Differential mobilization of subsets of progenitor cells from the bone marrow. Cell Stem Cell 4:62-72.

143. Richter,R., P.Casarosa, L.Standker, J.Munch, J.Y.Springael, S.Nijmeijer, W.G.Forssmann, H.F.Vischer, J.Vakili, M.Detheux, M.Parmentier, R.Leurs, and M.J.Smit. 2009. Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. J Immunol 183:1229-1237.

144. Santarlasci,V., L.Maggi, M.Capone, F.Frosali, V.Querci, R.De Palma, F.Liotta, L.Cosmi, E.Maggi, S.Romagnani, and F.Annunziato. 2009. TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells. Eur J Immunol 39:207-215.

145. Savino,B., E.M.Borroni, N.M.Torres, P.Proost, S.Struyf, A.Mortier, A.Mantovani, M.Locati, and R.Bonecchi. 2009. Recognition Versus Adaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence. J Biol Chem 284:26207-26215.

146. Segerer,S., Z.Johnson, A.Rek, T.Baltus, P.von Hundelshausen, A.J.Kungl, A.E.Proudfoot, C.Weber, and P.J.Nelson. 2009. The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic function. Mol Immunol 46:2533-2538.

147. Stahl-Hennig,C., M.Eisenblatter, E.Jasny, T.Rzehak, K.Tenner-Racz, C.Trumpfheller, A.M.Salazar, K.Uberla, K.Nieto, J.Kleinschmidt, R.Schulte, L.Gissmann, M.Muller, A.Sacher, P.Racz, R.M.Steinman, M.Uguccioni, and R.Ignatius. 2009. Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques. PLoS Pathog 5:e1000373.

148. Struyf,S., S.Noppen, T.Loos, A.Mortier, M.Gouwy, H.Verbeke, D.Huskens, S.Luangsay, M.Parmentier, K.Geboes, D.Schols, J.Van Damme, and P.Proost. 2009. Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4. J Immunol 182:666-674.

149. Struyf,S., P.Proost, J.Vandercappellen, S.Dempe, B.Noyens, S.Nelissen, M.Gouwy, M.Locati, G.Opdenakker, C.Dinsart, and J.Van Damme. 2009. Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects. Eur J Immunol 39:843-857.

150. Vielhauer,V., R.Allam, M.T.Lindenmeyer, C.D.Cohen, D.Draganovici, J.Mandelbaum, N.Eltrich, P.J.Nelson, H.J.Anders, M.Pruenster, A.Rot, D.Schlondorff, and S.Segerer. 2009. Efficient renal recruitment of macrophages and T cells in mice lacking the duffy antigen/receptor for chemokines. Am J Pathol 175:119-131.

151. Vielhauer,V. and H.J.Anders. 2009. Chemokines and chemokine receptors as therapeutic targets in chronic kidney disease. Front Biosci (Schol Ed) 1:1-12.

152. Villares,R., V.Cadenas, M.Lozano, L.Almonacid, A.Zaballos, A.C.Martinez, and R.Varona. 2009. CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur J Immunol 39:1671-1681.

153. Kuscher,K., G.Danelon, S.Paoletti, L.Stefano, M.Schiraldi, V.Petkovic, M.Locati, B.O.Gerber, and M.Uguccioni. 2009. Synergy-inducing chemokines enhance CCR2 ligand activities on monocytes. Eur J Immunol 39:1118-1128.

154. Rulli,N.E., A.Guglielmotti, G.Mangano, M.S.Rolph, C.Apicella, A.Zaid, A.Suhrbier, and S.Mahalingam. 2009. Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins. Arthritis Rheum. 60:2513-2523.

155. Lin,J., X.Zhu, A.R.Chade, K.L.Jordan, R.Lavi, E.Daghini, M.E.Gibson, A.Guglielmotti, A.Lerman, and L.O.Lerman. 2009. Monocyte Chemoattractant Proteins Mediate Myocardial Microvascular Dysfunction in Swine Renovascular Hypertension. Arterioscler.Thromb.Vasc.Biol.

156. Grassia,G., M.Maddaluno, A.Guglielmotti, G.Mangano, G.Biondi, P.Maffia, and A.Ialenti. 2009. The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc.Res.

157. Norata,G.D., P.Marchesi, V.K.Pulakazhi Venu, F.Pasqualini, A.Anselmo, F.Moalli, I.Pizzitola, C.Garlanda, A.Mantovani, and A.L.Catapano. 2009. Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis. Circulation 120:699-708.

158. Salogni,L., T.Musso, D.Bosisio, M.Mirolo, V.R.Jala, B.Haribabu, M.Locati, and S.Sozzani. 2009. Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood 113:5848-5856.

159. Bonecchi,R., E.Galliera, E.M.Borroni, M.M.Corsi, M.Locati, and A.Mantovani. 2009. Chemokines and chemokine receptors: an overview. Front Biosci 14:540-551.

160. Jensen,P.C. and M.M.Rosenkilde. 2009. Chapter 8. Activation mechanisms of chemokine receptors. Methods Enzymol. 461:171-190.

161. Colotta,F., P.Allavena, A.Sica, C.Garlanda, and A.Mantovani. 2009. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30:1073-1081.

162. Lech,M., A.Avila-Ferrufino, R.Allam, S.Segerer, A.Khandoga, F.Krombach, C.Garlanda, A.Mantovani, and H.J.Anders. 2009. Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein. J Immunol 183:4109-4118.

163. Vetrano,S., E.M.Borroni, A.Sarukhan, B.Savino, R.Bonecchi, C.Correale, V.Arena, M.Fantini, M.Roncalli, A.Malesci, A.Mantovani, M.Locati, and S.Danese. 2009. The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6. Gut.

164. Zhu,X.Y., A.R.Chade, J.D.Krier, E.Daghini, R.Lavi, A.Guglielmotti, A.Lerman, and L.O.Lerman. 2009. The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension. J Hypertens.

165. Duhen,T., R.Geiger, D.Jarrossay, A.Lanzavecchia, and F.Sallusto. 2009. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat.Immunol 10:857-863.

166. Napolitani,G., E.V.Acosta-Rodriguez, A.Lanzavecchia, and F.Sallusto. 2009. Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells. Eur J Immunol 39:1301-1312.

167. Reboldi,A., C.Coisne, D.Baumjohann, F.Benvenuto, D.Bottinelli, S.Lira, A.Uccelli, A.Lanzavecchia, B.Engelhardt, and F.Sallusto. 2009. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat.Immunol 10:514-523.

168. Thelen,M., L.M.Munoz, J.M.Rodriguez-Frade, and M.Mellado. 2009. Chemokine receptor oligomerization: functional considerations. Curr.Opin.Pharmacol.

169. Kendle M.Maslowski, Angelica T.Vieira, Aylwin Ng, Jan Kranich, Frederic Sierro, Di Yu, Heidi C. Schilter, Michael S.Rolph, Fabienne Mackay, David Artis, Ramnik J. Xavier, Mauro M. Teixeira & Charles R. Mackay. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461: 1282-1287.

Publications of the fifth year (Nov 2009-Oct 2010)

170. Moser, B., and M. Eberl. 2007. gammadelta T cells: novel initiators of adaptive immunity. Immunol Rev 215:89-102.

171. Meuter, S., and B. Moser. 2008. Constitutive expression of CXCL14 in healthy human and murine epithelial tissues. Cytokine 44:248-255.

172. Annunziato, F., L. Cosmi, F. Liotta, E. Maggi, and S. Romagnani. 2009. Type 17 T helper cells-origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol 5:325-331.

173. Annunziato, F., L. Cosmi, F. Liotta, E. Maggi, and S. Romagnani. 2009. Human Th17 cells: are they different from murine Th17 cells? Eur J Immunol 39:637-640.

174. Annunziato, F., and S. Romagnani. 2009. Heterogeneity of human effector CD4+ T cells. Arthritis Res Ther 11:257.

175. Benned-Jensen, T., and M. M. Rosenkilde. 2009. The role of transmembrane segment II in 7TM receptor activation. Curr Mol Pharmacol 2:140-148.

176. Brandes, M., K. Willimann, G. Bioley, N. Levy, M. Eberl, M. Luo, R. Tampe, F. Levy, P. Romero, and B. Moser. 2009. Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A 106:2307-2312.

177. Eberl, M., and B. Moser. 2009. Monocytes and gammadelta T cells: close encounters in microbial infection. Trends Immunol 30:562-568.

178. Eberl, M., G. W. Roberts, S. Meuter, J. D. Williams, N. Topley, and B. Moser. 2009. A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog 5:e1000308.

179. Gouwy, M., S. Struyf, H. Verbeke, W. Put, P. Proost, G. Opdenakker, and J. Van Damme. 2009. CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8. J Leukoc Biol 86:671-680.

180. Graham, G. J. 2009. D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes. Eur J Immunol 39:342-351.

181. Humby, F., M. Bombardieri, A. Manzo, S. Kelly, M. C. Blades, B. Kirkham, J. Spencer, and C. Pitzalis. 2009. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 6:e1.

182. Luangsay, S., V. Wittamer, B. Bondue, O. De Henau, L. Rouger, M. Brait, J. D. Franssen, P. de Nadai, F. Huaux, and M. Parmentier. 2009. Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model. J Immunol 183:6489-6499.

183. Maerki, C., S. Meuter, M. Liebi, K. Muhlemann, M. J. Frederick, N. Yawalkar, B. Moser, and M. Wolf. 2009. Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections. J Immunol 182:507-514.

184. Martinez Munoz, L., P. Lucas, G. Navarro, A. I. Checa, R. Franco, A. C. Martinez, J. M. Rodriguez-Frade, and M. Mellado. 2009. Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers. J
Immunol 183:7337-7346.

185. Maslowski, K. M., A. T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H. C. Schilter, M. S. Rolph, F. Mackay, D. Artis, R. J. Xavier, M. M. Teixeira, and C. R. Mackay. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282-1286.

186. McKimmie, C. S., M. Moore, A. R. Fraser, T. Jamieson, D. Xu, C. Burt, N. I. Pitman, R. J. Nibbs, I. B. McInnes, F. Y. Liew, and G. J. Graham. 2009. A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood 113:4224-4231.

187. Nibbs, R. J., P. McLean, C. McCulloch, A. Riboldi-Tunnicliffe, E. Blair, Y. Zhu, N. Isaacs, and G. J. Graham. 2009. Structure-function dissection of D6, an atypical scavenger receptor. Methods Enzymol

188. Patel, M., I. B. McInnes, and G. Graham. 2009. Atypical chemokine receptors in inflammatory disease. Curr Mol Med 9:86-93.

189. Pruenster, M., L. Mudde, P. Bombosi, S. Dimitrova, M. Zsak, J. Middleton, A. Richmond, G. J. Graham, S. Segerer, R. J. Nibbs, and A. Rot. 2009. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol 10:101-108.

190. Rodriguez-Frade, J. M., L. M. Munoz, B. L. Holgado, and M. Mellado. 2009. Chemokine receptor dimerization and chemotaxis. Methods Mol Biol 571:179-198.

191. Romagnani, S., E. Maggi, F. Liotta, L. Cosmi, and F. Annunziato. 2009. Properties and origin of human Th17 cells. Mol Immunol 47:3-7.

192. Schiffer, L., P. Kumpers, A. M. Davalos-Misslitz, M. Haubitz, H. Haller, H. J. Anders, T. Witte, and M. Schiffer. 2009. B-cell-attracting chemokine CXCL13 as a marker of disease activity and renal involvement in systemic lupus erythematosus (SLE). Nephrol Dial Transplant 24:3708-3712.

193. Sohy, D., H. Yano, P. de Nadai, E. Urizar, A. Guillabert, J. A. Javitch, M. Parmentier, and J. Y. Springael. 2009. Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists. J Biol Chem 284:31270-31279.

194. van de Pavert, S. A., B. J. Olivier, G. Goverse, M. F. Vondenhoff, M. Greuter, P. Beke, K. Kusser, U. E. Hopken, M. Lipp, K. Niederreither, R. Blomhoff, K. Sitnik, W. W. Agace, T. D. Randall, W. J. de Jonge, and R. E. Mebius. 2009. Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol 10:1193-1199.

195. Ye, R. D., F. Boulay, J. M. Wang, C. Dahlgren, C. Gerard, M. Parmentier, C. N. Serhan, and P. M. Murphy. 2009. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev 61:119-161.

196. Anders, H. J., S. A. Sayyed, and V. Vielhauer. 2010. Questions about chemokine and chemokine receptor antagonism in renal inflammation. Nephron Exp Nephrol 114:e33-38.

197. Annunziato, F., L. Cosmi, and S. Romagnani. 2010. Human and murine Th17. Curr Opin HIV AIDS 5:114-119.

198. Bedke, J., P. J. Nelson, E. Kiss, N. Muenchmeier, A. Rek, C. L. Behnes, N. Gretz, A. J. Kungl, and H. J. Grone. 2010. A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage. Mol Immunol 47:1047-1057.

199. Benned-Jensen, T., and M. M. Rosenkilde. 2010. Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. Br J Pharmacol 159:1092-1105.

200. Bonecchi, R., B. Savino, E. M. Borroni, A. Mantovani, and M. Locati. 2010. Chemokine decoy receptors: structure-function and biological properties. Curr Top Microbiol Immunol 341:15-36.

201. Borroni, E. M., A. Mantovani, M. Locati, and R. Bonecchi. 2010. Chemokine receptors intracellular trafficking. Pharmacol Ther 127:1-8.

202. Cochain, C., M. P. Rodero, J. Vilar, A. Recalde, A. L. Richart, C. Loinard, Y. Zouggari, C. Guerin, M. Duriez, B. Combadiere, L. Poupel, B. I. Levy, Z. Mallat, C. Combadiere, and J. S. Silvestre. 2010. Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization. Cardiovasc Res 88:186-195.

203. Cosmi, L., L. Maggi, V. Santarlasci, M. Capone, E. Cardilicchia, F. Frosali, V. Querci, R. Angeli, A. Matucci, M. Fambrini, F. Liotta, P. Parronchi, E. Maggi, S. Romagnani, and F. Annunziato. 2010. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol 125:222-230 e221-224.

204. Danese, S., and A. Mantovani. 2010. Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene 29:3313-3323.

205. de Graaf, K. L., M. H. Kosco-Vilbois, and N. Fischer. 2010. Therapeutic targeting of chemokines with monoclonal antibodies. Current Immunol Review Submitted.

206. Dehmel, S., S. Wang, C. Schmidt, E. Kiss, R. P. Loewe, S. Chilla, D. Schlondorff, H. J. Grone, and B. Luckow. 2010. Chemokine receptor Ccr5 deficiency induces alternative macrophage activation and improves long-term renal allograft outcome. Eur J Immunol 40:267-278.

207. Hopken, U. E., S. Winter, A. H. Achtman, K. Kruger, and M. Lipp. 2010. CCR7 regulates lymphocyte egress and recirculation through body cavities. J Leukoc Biol 87:671-682.

208. Khelashvili, G., K. Dorff, J. Shan, M. Camacho-Artacho, L. Skrabanek, B. Vroling, M. Bouvier, L. A. Devi, S. R. George, J. A. Javitch, M. J. Lohse, G. Milligan, R. R. Neubig, K. Palczewski, M. Parmentier, J. P. Pin, G. Vriend, F. Campagne, and M. Filizola. 2010. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics 26:1804-1805.

209. Locatelli, M., L. Boiocchi, S. Ferrero, F. Martinelli Boneschi, M. Zavanone, S. Pesce, P. Allavena, S. Maria Gaini, L. Bello, and A. Mantovani. 2010. Human glioma tumors express high levels of the chemokine receptor CX3CR1. Eur Cytokine Netw 21:27-33.

210. Lowe, R., and P. J. Nelson. 2010. Microarray Bioinformatics. In Biological Microarrays. Z. M. Suh K.Y. , Khademhosseini A., ed. Humana Press.

211. Madigan, J., D. J. Freeman, F. Menzies, S. Forrow, S. M. Nelson, A. Young, A. Sharkey, A. Moffett, G. J. Graham, I. A. Greer, A. Rot, and R. J. Nibbs. 2010. Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients. J Immunol 184:3202-3212.

212. Maggi, L., V. Santarlasci, M. Capone, A. Peired, F. Frosali, S. Q. Crome, V. Querci, M. Fambrini, F. Liotta, M. K. Levings, E. Maggi, L. Cosmi, S. Romagnani, and F. Annunziato. 2010. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol 40:2174-2181.

213. Manes, S., G. Fuentes, R. M. Peregil, A. M. Rojas, and R. A. Lacalle. 2010. An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells. FASEB J 24:3381-3392.

214. Mantovani, A. 2010. Molecular pathways linking inflammation and cancer. Curr Mol Med 10:369-373.

215. Mantovani, A., C. Garlanda, and P. Allavena. 2010. Molecular pathways and targets in cancer-related inflammation. Ann Med 42:161-170.

216. McKimmie, C. S., and G. J. Graham. 2010. Astrocytes modulate the chemokine network in a pathogen-specific manner. Biochem Biophys Res Commun 394:1006-1011.

217. Meuter, S., M. Eberl, and B. Moser. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells. Proc Natl Acad Sci U S A 107:8730-8735.

218. Mortier, A., M. Gouwy, J. Van Damme, and P. Proost. 2010. Effect of posttranslational processing on the in vivo activity of chemokines. Exp. Cell Res. Submitted.

219. Mortier, A., T. Loos, M. Gouwy, I. Ronsse, J. Van Damme, and P. Proost. 2010. Posttranslational modification of the NH2-terminal region of CXCL5 by proteases or peptidylarginine Deiminases (PAD) differently affects its biological activity. J Biol Chem 285:29750-29759.

220. Naumann, U., E. Cameroni, M. Pruenster, H. Mahabaleshwar, E. Raz, H. G. Zerwes, A. Rot, and M. Thelen. 2010. CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS One 5:e9175.

221. Nelson, P. J., and T. Werner. 2010. Pathways and promoter networks analysis provides systems topology for systems biology approaches. Semin Nephrol 30:477-486.

222. Norregaard, K., T. Benned-Jensen, and M. M. Rosenkilde. 2010. EBI2, GPR18, and GPR17 - Three Structurally Related but Biologically Distinct 7TM Receptors. in Press.

223. Pelletier, M., L. Maggi, A. Micheletti, E. Lazzeri, N. Tamassia, C. Costantini, L. Cosmi, C. Lunardi, F. Annunziato, S. Romagnani, and M. A. Cassatella. 2010. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115:335-343.

224. Rosenkilde, M. M., T. Benned-Jensen, T. M. Frimurer, and T. W. Schwartz. 2010. The minor binding pocket: a major player in 7TM receptor activation. Trends Pharmacol Sci.

225. Russo, R. C., A. L. Alessandri, C. C. Garcia, B. F. Cordeiro, V. Pinho, G. D. Cassali, A. E. Proudfoot, and M. M. Teixeira. 2010. Therapeutic Effects of Evasin-1, a Chemokine Binding Protein, in Bleomycin-Induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol.

226. Russo, R. C., C. C. Garcia, L. S. Barcelos, M. A. Rachid, R. Guabiraba, E. Roffe, A. L. Souza, L. P. Sousa, M. Mirolo, A. Doni, G. D. Cassali, V. Pinho, M. Locati, and M. M. Teixeira. 2010. Phosphoinositide 3-kinase {gamma} plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J Leukoc Biol.

227. Russo, R. C., C. C. Garcia, and M. M. Teixeira. 2010. Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists? Curr Opin Drug Discov Devel 13:414-427.

228. Scott-Algara, D., K. Balabanian, L. A. Chakrabarti, L. Mouthon, F. Dromer, C. Didier, F. Arenzana-Seisdedos, and O. Lortholary. 2010. Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4. Blood 115:3708-3717.

229. Struyf, S., L. Salogni, M. D. Burdick, J. Vandercappellen, M. Gouwy, S. Noppen, P. Proost, G. Opdenakker, M. Parmentier, C. Gerard, S. Sozzani, R. M. Strieter, and J. Van Damme. 2010. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood.

230. Teixeira, M. M., M. C. Vilela, F. M. Soriani, D. H. Rodrigues, and A. L. Teixeira. 2010. Using intravital microscopy to study the role of chemokines during infection and inflammation in the central nervous system. J Neuroimmunol 224:62-65.

231. Thelen, M., L. M. Munoz, J. M. Rodriguez-Frade, and M. Mellado. 2010. Chemokine receptor oligomerization: functional considerations. Curr Opin Pharmacol 10:38-43.

232. Vandercappellen, J., S. Liekens, A. Bronckaers, S. Noppen, I. Ronsse, C. Dillen, M. Belleri, S. Mitola, P. Proost, M. Presta, S. Struyf, and J. Van Damme. 2010. The COOH-terminal peptide of platelet factor-4 variant (CXCL4L1/PF-4var47-70) strongly inhibits angiogenesis and suppresses B16 melanoma growth in vivo. Mol Cancer Res 8:322-334.

233. Vandercappellen, J., J. Van Damme, and S. Struyf. 2010. The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer. Cytokine Growth Factor Rev.

234. Venetz, D., M. Ponzoni, M. Schiraldi, A. J. Ferreri, F. Bertoni, C. Doglioni, and M. Uguccioni. 2010. Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T cell
infiltration and positioning of malignant B cells. Int J Cancer 127:2300-2312.

235. Verbeke, H., G. De Hertogh, S. Li, J. Vandercappellen, S. Noppen, E. Schutyser, A. A. El-Asrar, G. Opdenakker, J. Van Damme, K. Geboes, and S. Struyf. 2010. Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer. Hum Pathol 41:990-1001.

236. Vetrano, S., E. M. Borroni, A. Sarukhan, B. Savino, R. Bonecchi, C. Correale, V. Arena, M. Fantini, M. Roncalli, A. Malesci, A. Mantovani, M. Locati, and S. Danese. 2010. The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6. Gut 59:197-206.

237. Vieira, C. R., J. M. Munoz-Olaya, J. Sot, S. Jimenez-Baranda, N. Izquierdo-Useros, J. L. Abad, B. Apellaniz, R. Delgado, J. Martinez-Picado, A. Alonso, J. Casas, J. L. Nieva, G. Fabrias, S. Manes, and F. M. Goni. 2010. Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains. Chem Biol 17:766-775.

238. Vielhauer, V., O. Kulkarni, C. A. Reichel, and H. J. Anders. 2010. Targeting the recruitment of monocytes and macrophages in renal disease. Semin Nephrol 30:318-333.

239. Winter, S., C. Loddenkemper, A. Aebischer, K. Rabel, K. Hoffmann, T. F. Meyer, M. Lipp, and U. E. Hopken. 2010. The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation. J Mol Med 88:1169-1180.

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